Summary of DuBuc et al, 2018. Homologizing the oral/aboral axis in Cnidaria to the anteroposterior axis in Bilateria. The top panel shows anterior (red) and central/posterior (dark green) Hox gene expression patterns in representative Bilateria, including a vertebrate, an annelid, and an insect. Bottom panel shows the results of perturbation experiments in Nematostella. DuBuc et al raised (up arrow) or lowered (down arrow) the expression levels of an anterior Hox gene (Ax6) and a posterior Hox gene (Ax1). They found that lowering Ax6 or raising Ax1 caused a loss of anterior structures and a mispatternig of the endomesoderm. Raising Ax6 or lowering Ax1 caused the formation of extra oral tissue and lowering Ax1 additionally caused the loss of aboral structures. Together these data support the homology between the oral/aboral axis of Cnidaria to the anteroposterior axis of Bilateria
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evolution, development, evodevo, gene expression, Hox, Nematostella, cnidarian, Wnt, oral, aboral, endomesoderm