School or College
College of the Pacific
Department
Chemistry
Location
William Knox Holt Memorial Library and Learning Center
Description
Triplex DNA formation has attracted interest in anti-gene therapy as it can interfere with many pathogenic activities, including replication halt and gene expression regulation. Triplex DNA is not as stable as duplex DNA under physiological conditions. Small molecules, known as anti-gene enhancers, have been used to facilitate the formation of triplex DNA. In the present work, I report the discovery of a novel class of small molecules that can bind to triplex DNA with high affinities but do not influence the structures of duplex DNA.
Discovery of Novel Triplex DNA Binding Ligands
William Knox Holt Memorial Library and Learning Center
Triplex DNA formation has attracted interest in anti-gene therapy as it can interfere with many pathogenic activities, including replication halt and gene expression regulation. Triplex DNA is not as stable as duplex DNA under physiological conditions. Small molecules, known as anti-gene enhancers, have been used to facilitate the formation of triplex DNA. In the present work, I report the discovery of a novel class of small molecules that can bind to triplex DNA with high affinities but do not influence the structures of duplex DNA.
