Presentation Category
Other
Introduction/Context/Diagnosis
P. gingivalis, a prevalent bacteria in the oral cavity of patients with active periodontitis, presents a persistent challenge. Patients often receive root debridement therapy to manage disease progression, however, it merely addresses symptoms without curing or reversing the condition. Therefore, there is a pressing need for more sophisticated therapeutic approaches, such as vaccination, targeting the pathogen directly. Although comprehensive research involving human clinical trials are pending, the aim of this invention is to introduce specific antigens of periodontitis to stimulate the targeted antibodies. The periodontitis vaccine has the potential to become a supplement to mechanical therapy. The comprehensive literature review from peer reviewed PubMed resources will determine if immunization with a P. gingivalis vaccine has the potential to reduce progression of periodontal disease in adults with active periodontal disease during a four to six-week recall period. This can minimize the morbidity that is linked to periodontitis in adults and mitigate the impact of the disease. Examining existing studies for periodontal vaccinations and delving into potential future developments, the research provides insights to advancements for effectively managing the significant concern in periodontal health, providing patients with a more comprehensive treatment approach.
Location
Arthur A Dugoni School of Dentistry, 155 5th St, San Francisco, CA 94103, USA
Format
Presentation
Exploring the Potential of Periodontitis Vaccines: A Comprehensive Review and Analysis
Arthur A Dugoni School of Dentistry, 155 5th St, San Francisco, CA 94103, USA
P. gingivalis, a prevalent bacteria in the oral cavity of patients with active periodontitis, presents a persistent challenge. Patients often receive root debridement therapy to manage disease progression, however, it merely addresses symptoms without curing or reversing the condition. Therefore, there is a pressing need for more sophisticated therapeutic approaches, such as vaccination, targeting the pathogen directly. Although comprehensive research involving human clinical trials are pending, the aim of this invention is to introduce specific antigens of periodontitis to stimulate the targeted antibodies. The periodontitis vaccine has the potential to become a supplement to mechanical therapy. The comprehensive literature review from peer reviewed PubMed resources will determine if immunization with a P. gingivalis vaccine has the potential to reduce progression of periodontal disease in adults with active periodontal disease during a four to six-week recall period. This can minimize the morbidity that is linked to periodontitis in adults and mitigate the impact of the disease. Examining existing studies for periodontal vaccinations and delving into potential future developments, the research provides insights to advancements for effectively managing the significant concern in periodontal health, providing patients with a more comprehensive treatment approach.
Comments/Acknowledgements
Presentation Category: PIP: Bench or Clinical Research