Caenorhabditis elegans as a Convenient Animal Model for Microbiome Studies

Authors

Cheng-Yeu Wu, Chang Gung UniversityFollow
Scott Davis, University of the PacificFollow
Neekita Saudagar, University of the PacificFollow
Shrey Shah, University of the PacificFollow
William Zhao, University of the PacificFollow
Arnold Stern, New York University
Jan Martel, Chang Gung UniversityFollow
David M. Ojcius, University of the PacificFollow
Hung-Chi Yang, Yuanpei University of Medical TechnologyFollow

ORCiD

David Ojcius: https://orcid.org/0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

International Journal of Molecular Sciences

ISSN

1422-0067

Volume

25

Issue

12

DOI

10.3390/ijms25126670

First Page

1

Last Page

13

Publication Date

6-18-2024

Abstract

Microbes constitute the most prevalent life form on Earth, yet their remarkable diversity remains mostly unrecognized. Microbial diversity in vertebrate models presents a significant challenge for investigating host–microbiome interactions. The model organism Caenorhabditis elegans has many advantages for delineating the effects of host genetics on microbial composition. In the wild, the C. elegans gut contains various microbial species, while in the laboratory it is usually a host for a single bacterial species. There is a potential host–microbe interaction between microbial metabolites, drugs, and C. elegans phenotypes. This mini-review aims to summarize the current understanding regarding the microbiome in C. elegans. Examples using C. elegans to study host–microbe–metabolite interactions are discussed.

Recommended Citation

Wu, C., Davis, S., Saudagar, N., Shah, S., Zhao, W., Stern, A., Martel, J., Ojcius, D. M., & Yang, H. (2024). Caenorhabditis elegans as a Convenient Animal Model for Microbiome Studies. International Journal of Molecular Sciences, 25(12), 1–13. DOI: 10.3390/ijms25126670
https://scholarlycommons.pacific.edu/dugoni-facarticles/870