Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways

Authors

Huan Wang, Zhejiang University School of Medicine,
Yifei Hu, Zhejiang University School of Medicine,
David M. Ojcius, University of California, MercedFollow
X. Frank Yang, Indiana University School of Medicine
Chenglin Zhang, Zhejiang University School of Medicine,
Shibiao Ding, Zhejiang University School of Medicine,
Xu'ai Lin, Zhejiang University School of Medicine,
Jie Yan, Zhejiang University School of Medicine,

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

PLoS One

ISSN

1932-6203

Volume

7

Issue

8

DOI

10.1371/journal.pone.0042266

First Page

1

Last Page

15

Publication Date

8-1-2012

Abstract

Infection with pathogenic Leptospira species causes serious systemic inflammation in patients. Although a few leptospiral proinflammatory molecules have been identified, Leptospira likely encodes other unidentified strong inflammation stimulators. The pathogenic L. interrogans genome encodes numerous putative hemolysin genes. Since hemolysins from other bacteria can cause inflammatory reactions, we hypothesized that leptospiral hemolysins may function as proinflammatory stimulators that contribute to the strong inflammation associated with Leptospira infection.

Comments

Article e42266

Recommended Citation

Wang, H., Hu, Y., Ojcius, D. M., Yang, X. F., Zhang, C., Ding, S., Lin, X., & Yan, J. (2012). Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways. PLoS One, 7(8), 1–15. DOI: 10.1371/journal.pone.0042266
https://scholarlycommons.pacific.edu/dugoni-facarticles/78