Department
Biomedical Sciences
Document Type
Article
Publication Title
Seminars in Immunopathology
ISSN
1863-2297
Volume
42
Issue
4
DOI
10.1007/s00281-019-00772-1
First Page
397
Last Page
412
Publication Date
8-1-2020
Abstract
Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy “immune clock” is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, placental, and maternal pacemakers that program the immune clock of pregnancy. We will then emphasize multiomic studies that enable a more integrated view of pregnancy-related immune adaptations. Such multiomic assessments can strengthen the biological plausibility of immunological findings and increase the power of biological signatures predictive of preterm birth.
Recommended Citation
Peterson, L. S.,
Stelzer, I. A.,
Tsai, A. S.,
Ghaemi, M.,
Han, X.,
Ando, K.,
Winn, V. D.,
Martinez, N. R.,
Contrepois, K.,
Moufarrej, M. N.,
Quake, S.,
Relman, D. A.,
Snyder, M. P.,
Shaw, G. M.,
Stevenson, D. K.,
Wong, R. J.,
Arck, P.,
Angst, M. S.,
Aghaeepour, N.,
&
Gaudilliere, B.
(2020).
Multiomic immune clockworks of pregnancy.
Seminars in Immunopathology, 42(4), 397–412.
DOI: 10.1007/s00281-019-00772-1
https://scholarlycommons.pacific.edu/dugoni-facarticles/717
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This work is licensed under a Creative Commons Attribution 4.0 International License.
