Title

Porphyromonas gingivalis stimulates IL-18 secretion in human monocytic THP-1 cells

ORCiD

Nejat Düzgüneş: 0000-0001-6159-1391

Document Type

Article

Publication Title

Microbes and Infection

ISSN

1286-4579

Volume

14

Issue

9

DOI

10.1016/j.micinf.2012.03.002

First Page

684

Last Page

689

Publication Date

8-1-2012

Abstract

Porphyromonas gingivalis is a major pathogen implicated in chronic periodontitis. We examined whether P. gingivalis affected the secretion of the pro-inflammatory cytokine interleukin-18 (IL-18) in macrophage-like THP-1 cells and in monocytic THP-1 cells in suspension. Live P. gingivalis-induced significant IL-18 secretion. Heat-inactivation of P. gingivalis greatly reduced the IL-18 stimulation; the IL-18 levels were similar to that observed with P. gingivalis LPS alone. Live P. gingivalis caused a cytotoxic effect that was reduced greatly by heat-inactivation. Our observations indicate that P. gingivalis specifically stimulates the production and release of the active form of IL-18, which may contribute to the progression of periodontitis. © 2012 Institut Pasteur.

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