Porphyromonas gingivalis stimulates IL-18 secretion in human monocytic THP-1 cells
ORCiD
Nejat Düzgüneş: 0000-0001-6159-1391
Department
Biomedical Sciences
Document Type
Article
Publication Title
Microbes and Infection
ISSN
1286-4579
Volume
14
Issue
9
DOI
10.1016/j.micinf.2012.03.002
First Page
684
Last Page
689
Publication Date
8-1-2012
Abstract
Porphyromonas gingivalis is a major pathogen implicated in chronic periodontitis. We examined whether P. gingivalis affected the secretion of the pro-inflammatory cytokine interleukin-18 (IL-18) in macrophage-like THP-1 cells and in monocytic THP-1 cells in suspension. Live P. gingivalis-induced significant IL-18 secretion. Heat-inactivation of P. gingivalis greatly reduced the IL-18 stimulation; the IL-18 levels were similar to that observed with P. gingivalis LPS alone. Live P. gingivalis caused a cytotoxic effect that was reduced greatly by heat-inactivation. Our observations indicate that P. gingivalis specifically stimulates the production and release of the active form of IL-18, which may contribute to the progression of periodontitis. © 2012 Institut Pasteur.
Recommended Citation
Yee, M.,
Kim, A.,
Alpagot, T.,
Düzgüneş, N.,
&
Konopka, K.
(2012).
Porphyromonas gingivalis stimulates IL-18 secretion in human monocytic THP-1 cells.
Microbes and Infection, 14(9), 684–689.
DOI: 10.1016/j.micinf.2012.03.002
https://scholarlycommons.pacific.edu/dugoni-facarticles/679
