ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Microbial Cell

ISSN

2311-2638

Volume

7

Issue

10

DOI

10.15698/MIC2020.10.731

First Page

255

Last Page

269

Publication Date

7-9-2020

Abstract

The nematode Caenorhabditis elegans is a useful model to study aging due to its short lifespan, ease of manipulation, and available genetic tools. Several molecules and extracts derived from plants and fungi extend the lifespan of C. elegans by modulating aging-related pathways that are conserved in more complex organisms. Modulation of aging pathways leads to activation of autophagy, mitochondrial biogenesis and expression of antioxidant and detoxifying enzymes in a manner similar to caloric restriction. Low and moderate concentrations of plant and fungal molecules usually extend lifespan, while high concentrations are detrimental, consistent with a lifespan-modulating mechanism involving hormesis. We review here molecules and extracts derived from plants and fungi that extend the lifespan of C. elegans, and explore the possibility that these natural substances may produce health benefits in humans.

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Dentistry Commons

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