ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Microbial Cell
ISSN
2311-2638
Volume
7
Issue
10
DOI
10.15698/MIC2020.10.731
First Page
255
Last Page
269
Publication Date
7-9-2020
Abstract
The nematode Caenorhabditis elegans is a useful model to study aging due to its short lifespan, ease of manipulation, and available genetic tools. Several molecules and extracts derived from plants and fungi extend the lifespan of C. elegans by modulating aging-related pathways that are conserved in more complex organisms. Modulation of aging pathways leads to activation of autophagy, mitochondrial biogenesis and expression of antioxidant and detoxifying enzymes in a manner similar to caloric restriction. Low and moderate concentrations of plant and fungal molecules usually extend lifespan, while high concentrations are detrimental, consistent with a lifespan-modulating mechanism involving hormesis. We review here molecules and extracts derived from plants and fungi that extend the lifespan of C. elegans, and explore the possibility that these natural substances may produce health benefits in humans.
Recommended Citation
Martel, J.,
Wu, C.,
Peng, H.,
Ko, Y.,
Yang, H.,
Young, J. D.,
&
Ojcius, D. M.
(2020).
Plant and fungal products that extend lifespan in caenorhabditis elegans.
Microbial Cell, 7(10), 255–269.
DOI: 10.15698/MIC2020.10.731
https://scholarlycommons.pacific.edu/dugoni-facarticles/516
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
