Title

Emerging use of senolytics and senomorphics against aging and chronic diseases

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Medicinal Research Reviews

ISSN

01986325

DOI

10.1002/med.21702

Publication Date

1-1-2020

Abstract

© 2020 Wiley Periodicals LLC Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.

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