Title

Hormetic Effects of Phytochemicals on Health and Longevity.

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Trends in Endocrinology and Metabolism

ISSN

1879-3061

Volume

30

Issue

6

DOI

10.1016/j.tem.2019.04.001

First Page

335

Last Page

346

Publication Date

6-1-2019

Abstract

Caloric restriction, intermittent fasting, and exercise activate defensive cellular responses such as autophagy, DNA repair, and the induction of antioxidant enzymes. These processes improve health and longevity by protecting cells and organs against damage, mutations, and reactive oxygen species. Consuming a diet rich in vegetables, fruits, and mushrooms can also improve health and longevity. Phytochemicals such as alkaloids, polyphenols, and terpenoids found in plants and fungi activate the same cellular processes as caloric restriction, fasting, and exercise. Many of the beneficial effects of fruits and vegetables may thus be due to activation of stress resistance pathways by phytochemicals. A better understanding of the mechanisms of action of phytochemicals may provide important insights to delay aging and prevent chronic diseases.

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