Hormetic Effects of Phytochemicals on Health and Longevity.
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Trends in Endocrinology and Metabolism
ISSN
1879-3061
Volume
30
Issue
6
DOI
10.1016/j.tem.2019.04.001
First Page
335
Last Page
346
Publication Date
6-1-2019
Abstract
Caloric restriction, intermittent fasting, and exercise activate defensive cellular responses such as autophagy, DNA repair, and the induction of antioxidant enzymes. These processes improve health and longevity by protecting cells and organs against damage, mutations, and reactive oxygen species. Consuming a diet rich in vegetables, fruits, and mushrooms can also improve health and longevity. Phytochemicals such as alkaloids, polyphenols, and terpenoids found in plants and fungi activate the same cellular processes as caloric restriction, fasting, and exercise. Many of the beneficial effects of fruits and vegetables may thus be due to activation of stress resistance pathways by phytochemicals. A better understanding of the mechanisms of action of phytochemicals may provide important insights to delay aging and prevent chronic diseases.
Recommended Citation
Martel, J.,
Ojcius, D. M.,
Ko, Y.,
Ke, P.,
Wu, C.,
Peng, H.,
&
Young, J.
(2019).
Hormetic Effects of Phytochemicals on Health and Longevity..
Trends in Endocrinology and Metabolism, 30(6), 335–346.
DOI: 10.1016/j.tem.2019.04.001
https://scholarlycommons.pacific.edu/dugoni-facarticles/462
