ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
PLoS One
ISSN
1932-6203
Volume
14
Issue
4
DOI
10.1371/journal.pone.0215689
First Page
1
Last Page
9
Publication Date
1-1-2019
Abstract
Inflammation plays a critical role in initiation of adaptive immunity, pathogen clearance and tissue repair. Interleukin (IL)-1β is a potent pro-inflammatory cytokine and therefore its production is tightly regulated: its secretion requires the assembly of a macromolecular protein complex, termed the inflammasome. Aberrant activation of the inflammasome has been linked to debilitating human diseases including chronic inflammatory and autoimmune diseases. Thus, there is a great interest in understanding how inflammasomes are regulated. Here we show that Dicer, an enzyme necessary for the production of mature micro-RNAs (miRNAs), is required for optimal activation of NLRP3 inflammasomes in bone marrow macrophages. Our data indicate that miRNAs may play an important role in promoting inflammasome activation.
Recommended Citation
Ojcius, D. M.,
Jafari, A.,
Yeruva, L.,
Schindler, C. W.,
&
Abdul-Sater, A. A.
(2019).
Dicer regulates activation of the NLRP3 inflammasome.
PLoS One, 14(4), 1–9.
DOI: 10.1371/journal.pone.0215689
https://scholarlycommons.pacific.edu/dugoni-facarticles/458
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
