Title

Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death

ORCiD

Dr. Benjamin D. Zeitlin: 0000-0003-0110-0188

Document Type

Article

Publication Title

Clinical Cancer Research

ISSN

1078-0432

Volume

15

Issue

24

DOI

10.1158/1078-0432.CCR-09-2578

First Page

7453

Last Page

7455

Publication Date

Winter 12-15-2009

Abstract

Two genes are considered synthetic lethal if mutation of either alone allows cell viability, whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the dependency of Wnt/beta-catenin-addicted colorectal cancer cells on vascular endothelial growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this malignancy. (Clin Cancer Res 2009;15(24):7453-5)