Department

Orthodontics

Document Type

Article

Publication Title

Pathophysiology

ISSN

0928-4680

Volume

in press

DOI

10.1016/j.pathophys.2017.04.001

First Page

1

Last Page

5

Publication Date

4-11-2017

Abstract

Traumatic neuroma is neuronal tissue proliferation developed in a nerve injury site, often associatedwith increased sensitivity and spontaneous or evoked neuropathic pain. The mechanisms leading to the disorganized nerve proliferation are not completely understood, though inflammation in the injured nerve vicinity most likely has a role in the process. Inflammatory cytokines are also known to be involvedin the maintenance and development of post-traumatic and neuropathic pain. The goal of this study wasto quantify and compare pro and anti-inflammatory cytokines (TNF- , IL-1 , IL-6 and IL-10) levels innerves that formed neuromas and nerves that did not, following sciatic nerve transection.

A total of 30 rats were used in this study. Twenty rats underwent sciatic nerve transection and 10underwent sham surgery. Six weeks post-surgery nerve sections were collected and histologically eval-uated for neuroma formation. The samples were then classified as neuroma, non-neuroma and shamgroups. TNF- , IL-1 , IL-6 and IL-10 levels were measured in the nerves employing ELISA. TNF- levels were significantly higher in both neuroma and non-neuroma-forming injured nerves compared to thesham group. IL-1 and IL-6 levels were significantly higher in the neuroma-forming nerves compared tothe sham group. IL-10 levels were significantly higher in the non-neuroma group compared to the shamgroup. In conclusion IL-6, and IL-1 may have a role in the formation of traumatic neuroma while IL-10may inhibit neuroma formation.

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