Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity
David M. Ojcius: 0000-0003-1461-4495
Antimicrobial Agents and Chemotherapy
Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.
Abdul-Sater, A. A.,
Ojcius, D. M.,
Meyer, M. P.
Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity.
Antimicrobial Agents and Chemotherapy, 52(7), 2660–2662.