Purinergic signaling during Porphyromonas gingivalis infection

ORCiD

David M. Ojcius: 0000-0003-1461-4495; Ana C. Morandini: 0000-0003-4749-571X; Cassio Almeida-da-Silva: 0000-0001-9173-7208

Department

Biomedical Sciences

Document Type

Article

Publication Title

Biomedical Journal

ISSN

2319-4170

Volume

39

Issue

4

DOI

10.1016/j.bj.2016.08.003

First Page

251

Last Page

260

Publication Date

8-1-2016

Abstract

Despite recent advances unraveling mechanisms of host–pathogen interactions in innate immunity, the participation of purinergic signaling in infection-driven inflammation remains an emerging research field with many unanswered questions. As one of the most-studied oral pathogens, Porphyromonas gingivalis is considered as a keystone pathogen with a central role in development of periodontal disease. This pathogen needs to evade immune-mediated defense mechanisms and tolerate inflammation in order to survive in the host. In this review, we summarize evidence showing that purinergic signaling modulates P. gingivalis survival and cellular immune responses, and discuss the role played by inflammasome activation and cell death during P. gingivalis infection.

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