Solution Geometry and Long-Range Coupling in Carbohydrate Mimetics from Glycal Dimerization
239th American Chemical Society (ACS) National Meeting
American Chemical Society (ACS)
San Francisco, CA
March 21-25, 2010
Date of Presentation
The solution structures of three carbohydrate mimetics with gluco-, cellobio- and lacto-configurations from glycal dimerization are discussed. NOE experiments were used to establish the conformation across the glycosidic bond for both tetrasaccharide mimetics. J-resolved HMBC NMR experiments were used to measure long-range H,C coupling constants derived from iterative fitting of sin(pJHCt). The structures were found to be rigid with very little conformational averaging across the direct C-C-linkage.
Franz, A. H.
Solution Geometry and Long-Range Coupling in Carbohydrate Mimetics from Glycal Dimerization.
Paper presented at 239th American Chemical Society (ACS) National Meeting in San Francisco, CA.