pH-Sensitive, Ortho Ester-Based Cationic Lipoplexes for Gene Delivery

Authors

Xin Guo, University of the PacificFollow
H. Chen
Andreas H. Franz, University of the PacificFollow
H. ZhangFollow
Francis C. Szoka
Vyacheslav V. Samoshin, University of the PacificFollow

Document Type

Poster

Department

Chemistry

Conference Title

3rd International Conference on Colloid Chemistry and Physicochemical Mechanics (ICC 2008)

Location

Moscow, Russia

Conference Dates

June 24-28, 2008

Date of Presentation

6-24-2008

Abstract

We report our recent findings on pH-sensitive, ortho ester-based cationic lipids and their lipoplexes for gene delivery. At higher pH, such lipids were relatively stable and readily condensed with plasmid DNA into cationic lipoplexes. At lowered pH, such lipids rapidly hydrolysed, which in turn triggered their lipoplexes to destabilize the endosome membrane.

Comments

Click here to view the Conference's website

Recommended Citation

Guo, X., Chen, H., Franz, A. H., Zhang, H., Szoka, F. C., & Samoshin, V. V. (2008). pH-Sensitive, Ortho Ester-Based Cationic Lipoplexes for Gene Delivery. Paper presented at 3rd International Conference on Colloid Chemistry and Physicochemical Mechanics (ICC 2008) in Moscow, Russia.
https://scholarlycommons.pacific.edu/cop-facpres/329