Trans-2-Aminocyclohexanol-based lipids as pH-sensitive conformational switches for the PEG-grafted liposomes
239th American Chemical Society (ACS) National Meeting
American Chemical Society (ACS)
San Francisco, CA
March 21-25, 2010
Date of Presentation
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: a protonation-induced conformational change of the built-in trans-2-aminocyclohexanol moiety. In liposomes, this ring flip loosens packing of the attached lipid tails, leading to contents leakage. Herein we report our latest studies on the pH-sensitivity of various PEG-grafted (sterically hindered) liposomes comprising trans-2-aminocyclohexanol-based lipids. These liposomes are stable at pH 7.4 and yet release their content in a few seconds at pH 5.3-5.5.
Samoshina, N. M.,
Franz, A. H.,
Samoshin, V. V.
Trans-2-Aminocyclohexanol-based lipids as pH-sensitive conformational switches for the PEG-grafted liposomes.
Paper presented at 239th American Chemical Society (ACS) National Meeting in San Francisco, CA.