Trans-2-Aminocyclohexanol-based lipids as pH-sensitive conformational switches for the PEG-grafted liposomes

Authors

Nataliya M. Samoshina, University of the PacificFollow
Xin Guo, University of the PacificFollow
Barbora Brazdova, University of the PacificFollow
Yu Zheng, University of the Pacific
Xin Liu, University of the Pacific
Andreas H. Franz, University of the PacificFollow
Vyacheslav V. Samoshin, University of the PacificFollow

Document Type

Poster

Department

Chemistry

Conference Title

239th American Chemical Society (ACS) National Meeting

Organization

American Chemical Society (ACS)

Location

San Francisco, CA

Conference Dates

March 21-25, 2010

Date of Presentation

3-24-2010

Abstract

Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: a protonation-induced conformational change of the built-in trans-2-aminocyclohexanol moiety. In liposomes, this ring flip loosens packing of the attached lipid tails, leading to contents leakage. Herein we report our latest studies on the pH-sensitivity of various PEG-grafted (sterically hindered) liposomes comprising trans-2-aminocyclohexanol-based lipids. These liposomes are stable at pH 7.4 and yet release their content in a few seconds at pH 5.3-5.5.

Comments

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Recommended Citation

Samoshina, N. M., Guo, X., Brazdova, B., Zheng, Y., Liu, X., Franz, A. H., & Samoshin, V. V. (2010). Trans-2-Aminocyclohexanol-based lipids as pH-sensitive conformational switches for the PEG-grafted liposomes. Paper presented at 239th American Chemical Society (ACS) National Meeting in San Francisco, CA.
https://scholarlycommons.pacific.edu/cop-facpres/322