Periodontitis and Alzheimer’s Disease: Is There a Connection?

Authors

• William Lundergan, University of the Pacific Arthur A. Dugoni School of DentistryFollow
• Kavitha Parthasarathy, University of the Pacific Arthur A. Dugoni School of DentistryFollow
• Navid Knight, University of the Pacific Arthur A. Dugoni School of DentistryFollow

Document Type

Article

Publication Title

Oral

Department

Periodontics

ISSN

26736373

Volume

4

Issue

1

DOI

10.3390/oral4010006

First Page

61

Last Page

73

Publication Date

1-22-2024

Abstract

The oral health/systemic health connection has been an area of research interest that increased dramatically during the 1990s. Periodontal disease has been associated with a number of systemic conditions, including cardiovascular disease, diabetes, pre-term low-birth-weight infants, respiratory conditions, rheumatoid arthritis, cancer, and Alzheimer’s disease. Inflammation is the obvious link that connects periodontal disease with these conditions, but is this association casual or causal? We will address the biologic plausibility, evidence from human studies, evidence from animal studies, and therapeutic interventions as we review the current understanding of the link between periodontitis and Alzheimer’s disease.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Lundergan, William; Parthasarathy, Kavitha; and Knight, Navid, "Periodontitis and Alzheimer’s Disease: Is There a Connection?" (2024). Pacific Faculty Work. 47.
https://scholarlycommons.pacific.edu/all-faculty/47