Liver proteome response to torpor in a basoendothermic mammal, Tenrec ecaudatus, provides insights into the evolution of homeothermy

Authors

• Jane I. Khudyakov, University of the PacificFollow
• Michael D. Treat, University of Nevada, Las Vegas
• Mikayla C. Shanafelt, University of the Pacific
• Jared S. Deyarmin, University of the Pacific
• Benjamin A. Neely, National Institute of Standards and Technology
• Frank van Breukelen, University of Nevada, Las Vegas

Document Type

Article

Publication Title

American Journal of Physiology Regulatory Integrative and Comparative Physiology

Department

Biological Sciences

ISSN

15221490

Volume

321

Issue

4

DOI

10.1152/ajpregu.00150.2021

First Page

R614

Last Page

R624

Publication Date

10-5-2021

Abstract

Many mammals use adaptive heterothermy (e.g., torpor, hibernation) to reduce metabolic demands of maintaining high body temperature (Tb). Torpor is typically characterized by coordinated declines in Tb and metabolic rate (MR) followed by active rewarming. Most hibernators experience periods of euthermy between bouts of torpor during which homeostatic processes are restored. In contrast, the common tenrec, a basoendothermic Afrotherian mammal, hibernates without interbout arousals and displays extreme flexibility in Tb and MR. We investigated the molecular basis of this plasticity in tenrecs by profiling the liver proteome of animals that were active or torpid with high and more stable Tb (∼32^◦C) or lower Tb (∼14^◦C). We identified 768 tenrec liver proteins, of which 50.9% were differentially abundant between torpid and active animals. Protein abundance was significantly more variable in active cold and torpid compared with active warm animals, suggesting poor control of proteostasis. Our data suggest that torpor in tenrecs may lead to mismatches in protein pools due to poor coordination of anabolic and catabolic processes. We propose that the evolution of endothermy leading to a more realized homeothermy of boreoeutherians likely led to greater coordination of homeostatic processes and reduced mismatches in thermal sensitivities of metabolic pathways.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Khudyakov, Jane I.; Treat, Michael D.; Shanafelt, Mikayla C.; Deyarmin, Jared S.; Neely, Benjamin A.; and van Breukelen, Frank, "Liver proteome response to torpor in a basoendothermic mammal, Tenrec ecaudatus, provides insights into the evolution of homeothermy" (2021). Pacific Faculty Work. 268.
https://scholarlycommons.pacific.edu/all-faculty/268