Crosstalk between the antioxidant and cell wall integrity systems in fungi by 2-hydroxy-4-methoxybenzaldehyde

Authors

• Jong H. Kim, USDA ARS Western Regional Research Center (WRRC)
• Kathleen L. Chan, USDA ARS Western Regional Research Center (WRRC)
• Christina C. Tam, USDA ARS Western Regional Research Center (WRRC)
• Luisa W. Cheng, USDA ARS Western Regional Research Center (WRRC)
• Kirkwood M. Land, University of the PacificFollow

Document Type

Article

Publication Title

Cogent Food and Agriculture

Department

Biological Sciences

ISSN

23311932

Volume

6

Issue

1

DOI

10.1080/23311932.2020.1823593

First Page

1

Last Page

7

Publication Date

9-24-2020

Abstract

We would like to comment on a recent study where the redox-modulatory anti-protozoal drug chloroquine has shown to trigger a crosstalk between the antioxidant and cell wall integrity systems in the yeast Saccharomyces cerevisiae. This note discusses the redox-active potential of the natural compound 2-hydroxy-4-methoxybenzaldehyde (2H4M) which could also serve as a potent redox-cycler in fungal (yeast, molds) pathogens. Using S. cerevisiae as a molecular tool, we determined how 2H4M negatively affected both the antioxidant and cell wall integrity systems of fungi, thus indicating a similar crosstalk between the two systems under 2H4M-induced toxicity. The crosstalk functions as a fungal defense against redox-active drugs/compounds or environmental cues, and therefore, could be an effective target for antifungal treatment.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Kim, Jong H.; Chan, Kathleen L.; Tam, Christina C.; Cheng, Luisa W.; and Land, Kirkwood M., "Crosstalk between the antioxidant and cell wall integrity systems in fungi by 2-hydroxy-4-methoxybenzaldehyde" (2020). Pacific Faculty Work. 251.
https://scholarlycommons.pacific.edu/all-faculty/251