Understanding the tumor microenvironment in head and neck squamous cell carcinoma

Authors

• Habib Sadeghi Rad, The University of Queensland
• Yavar Shiravand, Università degli Studi di Napoli Federico II
• Payar Radfar, University of Technology Sydney
• Rahul Ladwa, The University of Queensland
• Chris Perry, The University of Queensland
• Xiaoyuan Han, University of the PacificFollow
• Majid Ebrahimi Warkiani, University of Technology Sydney
• Mark N. Adams, QUT Centre for Genomics and Personalised Health
• Brett G.M. Hughes, The University of Queensland
• Ken O'Byrne, Princess Alexandra Hospital
• Arutha Kulasinghe, The University of Queensland

Document Type

Article

Publication Title

Clinical and Translational Immunology

Department

Biomedical Sciences

ISSN

20500068

Volume

11

Issue

6

DOI

10.1002/cti2.1397

First Page

1

Last Page

14

Publication Date

6-6-2022

Abstract

Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of tumors. While significant progress has been made using multimodal treatment, the 5-year survival remains at 50%. Developing effective therapies, such as immunotherapy, will likely lead to better treatment of primary and metastatic disease. However, not all HNSCC tumors respond to immune checkpoint blockade therapy. Understanding the complex cellular composition and interactions of the tumor microenvironment is likely to lead to new knowledge for effective therapies and treatment resistance. In this review, we discuss HNSCC characteristics, predictive biomarkers, factors influencing immunotherapy response, with a focus on the tumor microenvironment.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Rad, Habib Sadeghi; Shiravand, Yavar; Radfar, Payar; Ladwa, Rahul; Perry, Chris; Han, Xiaoyuan; Warkiani, Majid Ebrahimi; Adams, Mark N.; Hughes, Brett G.M.; O'Byrne, Ken; and Kulasinghe, Arutha, "Understanding the tumor microenvironment in head and neck squamous cell carcinoma" (2022). Pacific Faculty Work. 218.
https://scholarlycommons.pacific.edu/all-faculty/218