Time Domains of Hypoxia Responses and -Omics Insights

Authors

• James J. Yu, University of California, San Diego
• Amy L. Non, University of California, San Diego
• Erica C. Heinrich, UCR School of Medicine
• Wanjun Gu, University of California, San Diego
• Joe Alcock, UNM School of Medicine
• Esteban A. Moya, University of California, San Diego
• Elijah S. Lawrence, University of California, San Diego
• Michael S. Tift, University of North Carolina Wilmington
• Katie A. O'Brien, University of California, San Diego
• Jay F. Storz, University of Nebraska-Lincoln
• Anthony V. Signore, University of Nebraska-Lincoln
• Jane I. Khudyakov, University of the PacificFollow
• William K. Milsom, The University of British Columbia
• Sean M. Wilson, Loma Linda University School of Medicine
• Cynthia M. Beall, Case Western Reserve University
• Francisco C. Villafuerte, Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno
• Tsering Stobdan, University of California, San Diego
• Colleen G. Julian, University of Colorado Anschutz School of Medicine
• Lorna G. Moore, University of Colorado Anschutz
• Mark M. Fuster, University of California, San Diego
• Jennifer A. Stokes, Southwestern University
• Richard Milner, San Diego Biomedical Research Institute

Document Type

Article

Publication Title

Frontiers in Physiology

Department

Biological Sciences

ISSN

1664042X

Volume

13

Issue

1

DOI

10.3389/fphys.2022.885295

First Page

1

Last Page

25

Publication Date

8-8-2022

Abstract

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Yu, James J.; Non, Amy L.; Heinrich, Erica C.; Gu, Wanjun; Alcock, Joe; Moya, Esteban A.; Lawrence, Elijah S.; Tift, Michael S.; O'Brien, Katie A.; Storz, Jay F.; Signore, Anthony V.; Khudyakov, Jane I.; Milsom, William K.; Wilson, Sean M.; Beall, Cynthia M.; Villafuerte, Francisco C.; Stobdan, Tsering; Julian, Colleen G.; Moore, Lorna G.; Fuster, Mark M.; Stokes, Jennifer A.; and Milner, Richard, "Time Domains of Hypoxia Responses and -Omics Insights" (2022). Pacific Faculty Work. 188.
https://scholarlycommons.pacific.edu/all-faculty/188