Title

Optimizing the structure of TTR Ligands for Half-life Extension (TLHE) of Peptides

Lead Author Affiliation

Pharmaceutics and Medicinal Chemistry

Introduction

The tremendous therapeutic potential of peptides has not been fulfilled and potential peptide therapies that have failed far outnumber the successes so far. A major challenge impeding the more widespread use of peptides as therapeutics is their poor pharmacokinetic profile, due to short in vivo half-life resulting from inactivation by serum proteases and rapid elimination by kidneys.

Location

DUC Ballroom A&B

Format

Poster Presentation

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Apr 30th, 1:00 PM Apr 30th, 3:30 PM

Optimizing the structure of TTR Ligands for Half-life Extension (TLHE) of Peptides

DUC Ballroom A&B

The tremendous therapeutic potential of peptides has not been fulfilled and potential peptide therapies that have failed far outnumber the successes so far. A major challenge impeding the more widespread use of peptides as therapeutics is their poor pharmacokinetic profile, due to short in vivo half-life resulting from inactivation by serum proteases and rapid elimination by kidneys.