Small-Molecule Inhibitors Reveal a New Function for Bcl-2 as a Pro-angiogenic Signaling Molecule

Title

Small-Molecule Inhibitors Reveal a New Function for Bcl-2 as a Pro-angiogenic Signaling Molecule

ORCID

Dr. Benjamin D. Zeitlin: 0000-0003-0110-0188

Files

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Document Type

Contribution to Book

Book Title

Small-Molecule Inhibitors of Protein-Protein Interactions

Editor(s)

Lyubomir Vassilev and David Fry

Description

Cancer has a complex etiology and displays a wide range of cellular escape pathways that allow it to circumvent treatment. Signaling molecules functionally downstream of the circumvented pathways, and particularly at checkpoints where several of these pathways intersect, provide valuable targets for the development of novel anti-cancer drugs. Bcl-2, a pro-survival signaling molecule, is one such protein. This review examines the efficacy, potency, and function of several small molecule inhibitor drugs targeted to the Bcl-2 family of proteins. The review focuses on the compounds with most available data within the literature and discusses both the anti-cancer and the recently unveiled anti-angiogenic potential of this new class of drugs.

ISBN

978-3-642-17083-6

Publication Date

1-1-2011

Publisher

Springer

First Page

115

Last Page

137

Disciplines

Dentistry | Medicine and Health Sciences

Comments

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 348)

Small-Molecule Inhibitors Reveal a New Function for Bcl-2 as a Pro-angiogenic Signaling Molecule

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