Cytolytic peptides and proteins: Is there a common structural motif?
David M. Ojcius: 0000-0003-1461-4495
Trends in Biochemical Sciences
Pore-forming proteins or peptides (PFP) have now been isolated from a wide array of species ranging from humans to bacteria. A great number of these toxins lyse cells through a ‘barrel-stave’ mechanism, in which monomers of the toxin bind to and insert into the target membrane and then aggregate like barrel staves surrounding a central, water-filled pore. An evaluation of the secondary structures suggests that common secondary structures may be employed by most of these toxic PFP.
Ojcius, D. M.,
Young, J. D.
Cytolytic peptides and proteins: Is there a common structural motif?.
Trends in Biochemical Sciences, 16, 225–229.