ORCiD

David M. Ojcius: 0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

Reproductive Biology and Endocrinology

ISSN

1477-7827

Volume

1

DOI

10.1186/1477-7827-1-121

First Page

121

Last Page

127

Publication Date

12-2-2003

Abstract

The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune system at the feto-maternal interface, citing examples of the role played by microbial infections in fetal demise.

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