Title

Design of Biocompatible pH-Sensitive Liposomes for Drug and Gene Delivery

Document Type

Poster

Department

Chemistry

Conference Title

3rd International Conference on Colloid Chemistry and Physicochemical Mechanics (ICC 2008)

Location

Moscow, Russia

Conference Dates

June 24-28, 2008

Date of Presentation

6-26-2008

Abstract

Since the decrease of pH is involved in many pathological and physiological pathways, it serves as an attractive stimulus to trigger the release of a drug/gene delivery system. We report our recent approaches to the design of pH-sensitive and yet biocompatible lipids and liposomes, including lipids with an acid-labile ortho-ester linker and lipids with the trans-2-aminocyclohexanol moiety as a conformational switch of lipid tails.

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