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Date of Award

1975

Document Type

Thesis

Degree Name

Master of Science (M.S.)

Department

Graduate School

First Advisor

James C. King

First Committee Member

Warren J. Schneider

Second Committee Member

Patrick Catania

Third Committee Member

Ivan W. Rowland

Abstract

Through the years, various studies (1-5) have been done regarding the prevalent practice of adding one or more drugs to parenteral fluids. The greater variety of drugs being used intravenously, plus the formulation of newer and more complex parenteral fluids, has led to an increased awareness of potential incompatibilities existing between drug and solution. Recognition of the hazards of such extemporaneous combinations has necessitated the study of drug stability in solution.

The objective of this report is to determine compatibility characteristics of admixtures prepared from a series of balance intravenous electrolyte solutions and a group of commonly used therapeutic agents. Visual, spectrophotometric and microbiological assay techniques are to be used to establish the compatibility profiles of these admixtures.

Pages

113

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