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Date of Award
Master of Science (M.S.)
James C King
First Committee Member
Donald Y Barker
Second Committee Member
Carl C Reidesel
Third Committee Member
Ivon N Rowand
Within the past several years, a great deal of attention has been focused on the phenomena of drug-drug interactions and their importance in the therapeutic regimen of patients for whom multiple therapeutic agents might be indicated. The rather sudden concern for this aspect of medical and pharmaceutical practice is evidenced by the proliferation of literature devoted to the topic for both professions. While iatrogenic disease has long been recognized as one of the hazards inherent in prescribing practices, only isolated reports of specific interactions were found until recently. Although it cannot be said with certainty when the first interaction of two drugs was noticed, such possibilities began to come to light with the observation that concomitant administration of an antacid with a tetracycline would impair the absorption or the anti- biotic (1). A concerted effort to bring order to our recognising and understanding of such interactions has taken place only within the past ten years
Alexander, Michael Ray. (1971). A Retrospective Study of Drug Interactions and their Clinical Significance in 100 Hospitalized Patients. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/412
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