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Date of Award

1967

Document Type

Thesis

Degree Name

Master of Science (M.S.)

Department

Physiology and Pharmacology

First Advisor

Carl C. Riedesel

First Committee Member

J. P. N[?]

Second Committee Member

James C. King

Third Committee Member

E. E. Roscoe

Abstract

The substance choline, one of the quaternary nitrogen bases, has been the subject of a number of reviews and investigations. It has been described as a cholinergic agent, an inotropic agent, a vitamin, and perhaps in other ways. In spite of the interest shown in its action and uses, there is as yet very little information available as to the mechanism by which it is absorbed by the intestinal mucosa.

The studies referred to thus far leave the field open for additional investigation. No mention was found in the literature of studies on selective areas of absorption of choline in the small intestine, or whether enzyme inhibitors might produce an effect on rate of absorption. In view of the possibility that active transport, and thus enzyme activity, might be involved in choline absorption, it is conceivable that rate of choline absorption might be altered by such enzyme inhibitors as phlorizin and 2, 4-dinitrophenol. Selective areas of choline absorption, and the effects of several enzyme inhibitors were, then, selected as the areas for investigation in the study described here.

Pages

41

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