Date of Award


Document Type


Degree Name

Master of Science (M.S.)


Biological Sciences

First Advisor

Paul M. Orwin

First Committee Member

Geoffrey Lin-Cereghino

Second Committee Member

Skylar Carlson

Third Committee Member

Eric Thomas


Staphylococcus aureus is one of the leading causes of fatal nosocomial infections. Often, S. aureus can grow as a biofilm which protects the population from the surrounding environment. Strains of S. aureus are resistant to virtually all known antibiotics on the market. Variovorax paradoxus is a soil microbe with many unusual metabolic activities. It has been previously observed that, V. paradoxus can inhibit the growth of S. aureus when in co-culture. In this work we report on inhibition of S. aureus biofilm formation by V. paradoxus due to a suspected inhibitory soluble factor.





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