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Date of Award

1995

Document Type

Thesis - Pacific Access Restricted

Degree Name

Master of Science (M.S.)

Department

Biological Sciences

First Advisor

Fuad M. Nahhas

First Committee Member

Alice S. Hunter

Second Committee Member

Kishori Chaubal

Abstract

A retrospective study (1990-1994) of the activities of ampicillin, unisyn, augmentin, ticarcillin, tinentin, piperacillin, and zosyn against several thousand isolates belonging to 8 species of bacteria (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcensens, Morganella morganii, Proteus mirabilis, Pseudomonas aeruginosa and Staphylococcus aureus) in the Stockton area was reviewed. In addition, 233 isolates of the same species examined in 1994 were tested against the six penicillins and zosyn (in-house).

The study shows that clavulanic acid 1 amoxicillin (Augmentin) combination has better activity than sulbactam 1 ampicillin combination (Unisyn) against E. coli, equal efficacy against K. pneumoniae, P. mirabilis, s. aureus but lesser active against E. cloacae, S. marcensens and ~ morganii. A comparison between the combination-drugs of clavulanic acidlticarcillin (Timentin) and tazobactaml piperacillin (Zosyn) generally indicates that they are equally effective on s. marcensens, M. morganii, ~ mirabilis, and s. aureus. Zosyn shows slightly better activity against E. coli, K. pneumoniae, E. cloacae, and ~ aeruginosa.

Pages

53

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