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Date of Award
1995
Document Type
Thesis - Pacific Access Restricted
Degree Name
Master of Science (M.S.)
Department
Biological Sciences
First Advisor
Fuad M. Nahhas
First Committee Member
Alice S. Hunter
Second Committee Member
Kishori Chaubal
Abstract
A retrospective study (1990-1994) of the activities of ampicillin, unisyn, augmentin, ticarcillin, tinentin, piperacillin, and zosyn against several thousand isolates belonging to 8 species of bacteria (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcensens, Morganella morganii, Proteus mirabilis, Pseudomonas aeruginosa and Staphylococcus aureus) in the Stockton area was reviewed. In addition, 233 isolates of the same species examined in 1994 were tested against the six penicillins and zosyn (in-house).
The study shows that clavulanic acid 1 amoxicillin (Augmentin) combination has better activity than sulbactam 1 ampicillin combination (Unisyn) against E. coli, equal efficacy against K. pneumoniae, P. mirabilis, s. aureus but lesser active against E. cloacae, S. marcensens and ~ morganii. A comparison between the combination-drugs of clavulanic acidlticarcillin (Timentin) and tazobactaml piperacillin (Zosyn) generally indicates that they are equally effective on s. marcensens, M. morganii, ~ mirabilis, and s. aureus. Zosyn shows slightly better activity against E. coli, K. pneumoniae, E. cloacae, and ~ aeruginosa.
Pages
53
Recommended Citation
Kim, Danny S.. (1995). In-vitro activity of some broad-spectrum penicillins and beta lactamase inhibitors on selected bacteria. University of the Pacific, Thesis - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/2288
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