Campus Access Only
All rights reserved. This publication is intended for use solely by faculty, students, and staff of University of the Pacific. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.
Date of Award
Thesis - Pacific Access Restricted
Master of Science (M.S.)
Fuad M. Nahhas
First Committee Member
Alice S. Hunter
Second Committee Member
A retrospective study (1990-1994) of the activities of ampicillin, unisyn, augmentin, ticarcillin, tinentin, piperacillin, and zosyn against several thousand isolates belonging to 8 species of bacteria (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcensens, Morganella morganii, Proteus mirabilis, Pseudomonas aeruginosa and Staphylococcus aureus) in the Stockton area was reviewed. In addition, 233 isolates of the same species examined in 1994 were tested against the six penicillins and zosyn (in-house).
The study shows that clavulanic acid 1 amoxicillin (Augmentin) combination has better activity than sulbactam 1 ampicillin combination (Unisyn) against E. coli, equal efficacy against K. pneumoniae, P. mirabilis, s. aureus but lesser active against E. cloacae, S. marcensens and ~ morganii. A comparison between the combination-drugs of clavulanic acidlticarcillin (Timentin) and tazobactaml piperacillin (Zosyn) generally indicates that they are equally effective on s. marcensens, M. morganii, ~ mirabilis, and s. aureus. Zosyn shows slightly better activity against E. coli, K. pneumoniae, E. cloacae, and ~ aeruginosa.
Kim, Danny S.. (1995). In-vitro activity of some broad-spectrum penicillins and beta lactamase inhibitors on selected bacteria. University of the Pacific, Thesis - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/2288
To access this thesis/dissertation you must have a valid pacific.edu email address and log-in to Scholarly Commons.Find in PacificSearch
If you are the author and would like to grant permission to make your work openly accessible, please email