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Date of Award


Document Type

Thesis - Pacific Access Restricted

Degree Name

Master of Science (M.S.)


Graduate School

First Advisor

Madhukar Chaubal

First Committee Member

Marvin H. Malone

Second Committee Member

Howell Runion

Third Committee Member

David S. Fries


Panax ginseng C.A. Mey. (Araliaceae), which has been known in China for more than 4000 years, occupies a particular place among tonic remedies. Pharmacological investigations of the roots have shown that the basic effect of ginseng's action is its capacity to increase the nonspecific resistance of the organism to various untoward influences. In addition to ginseng, another plant of the Araliaceae family is used in a similar manner and is known as Siberian ginseng, Eleutherococcus senticosus (Rupr. et Maxim.) Maxim.). Its roots have been very extensively investigated by Russian scientists. Ginseng is reported to be shorter in duration and weaker in activity when compared to E. semicosus in respect to stimulant and tonic effects. 13 Chinese scientists have claimed that China Produced E. senticosus can exert a definite anti fatigue action. Less extensive studies have been reported on the berries of Schisandra chinensis (Turcz.) Baill. (Magnoliaceae). for its adaptogenic properties.

The main objective of the work reported in the following pages was to design and test a simpler and easier animal test model whereby multiple physiologic parameters such as Tn EKG and respiratory rates could be continuously and concurrently monitored. It was desired that the test model could be used repeatedly and rapidly to serve as a screen for all potential adaptogenic plants and their derivatives and extracts.



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