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Date of Award


Document Type


Degree Name

Master of Science (M.S.)


Graduate School

First Advisor

Fuad Nahhas

First Committee Member

Donald M. Pace

Second Committee Member

F. R. Hunter


Phenylbutazone was first synthesized in 1946 by H. Stenzyl during his investigation on pyrazole and pyrazoline derivatives. Although these compounds had been studied during the previous fifty years, the pharmacological properties were only recently recognized. It has been used clinically since 1952.

Two other pharmaceutical agents of the pyrazole group are phenazone and amidopyrine; these were used as early as the nineteenth century. While phenazone and aminopyrine have basic properties, phenylbutazone exhibits distinctly acidic ones and is capable of forming salts with organic and inorganic bases.

In order to achieve a more basic understanding of how phenylbutazone produces effects, the following brief survey of the work that has been done with this compound is presented.



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