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Date of Award


Document Type


Degree Name

Master of Science (M.S.)



First Advisor

W. H. Wadman

First Committee Member

Herschel Frye

Second Committee Member

Emerson G. Cobb


The carbohydrates play a vital role in the chemistry of the life processes. As man’s study of these processes, both fundamentally and in applied areas such as medicine, becomes ever more intensive, the limitations of our analytical procedures become ever more serious. While there are innumerable quantitative analytic procedures for the monosaccharides, there is a severe dearth of good micro colorimetric procedures. A particularly useful and widely used micro and semimicro procedure, based upon periodic acid oxidation, was originally introduced by Malaprade in France in 1928. In general, the consumption of the periodic acid in estimated by a back titration procedure involved the liberation of iodine by the excess periodic acid and subsequent estimation of the iodine by titration with thiosulfate.

We conceived of the idea of an appropriately chosen reagent that would react with periodic acid to yield a compound that was stable under the working conditions and would have a spectra significantly different from that of the parent compound.



Included in

Chemistry Commons



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