Global resting-state functional connectivity of neural oscillations in tinnitus with and without hearing loss

Authors

Carly Demopoulos, University of California, San Francisco
Xuan Duong, Pacific Graduate School of Psychology
Leighton B. Hinkley, University of California, San Francisco
Kamalini G. Ranasinghe, University of California, San Francisco
Danielle Mizuiri, University of California, San Francisco
Coleman Garrett, University of California, San Francisco
Susanne Honma, University of California, San Francisco
Jennifer Henderson-Sabes, University of California, San FranciscoFollow
Anne Findlay, University of California, San Francisco
Caroline Racine-Belkoura, University of California, San Francisco
Steven W. Cheung, University of California, San Francisco
Srikantan S. Nagarajan, University of California, San Francisco

Department

Audiology

Abstract

This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band-dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus with and without hearing loss.

Document Type

Article

Publication Date

7-1-2020

Publication Title

Human Brain Mapping

ISSN

1065-9471

Volume

41

Issue

10

DOI

10.1002/hbm.24981

First Page

2846

Last Page

2861

Recommended Citation

Demopoulos, Carly; Duong, Xuan; Hinkley, Leighton B.; Ranasinghe, Kamalini G.; Mizuiri, Danielle; Garrett, Coleman; Honma, Susanne; Henderson-Sabes, Jennifer; Findlay, Anne; Racine-Belkoura, Caroline; Cheung, Steven W.; and Nagarajan, Srikantan S., "Global resting-state functional connectivity of neural oscillations in tinnitus with and without hearing loss" (2020). All Faculty Scholarship. 61.
https://scholarlycommons.pacific.edu/shs-all/61

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.