Title

Cell Phones in the Lab: An App for the Dynamic Simulation of Voltage-Gated Ion Channels

Poster Number

15C

Lead Author Major

Bioengineering

Lead Author Status

Junior

Second Author Major

Computer Science

Second Author Status

Sophomore

Format

Poster Presentation

Faculty Mentor Name

Carlos A. Villalba-Galea

Faculty Mentor Email

cvillalbagalea@PACIFIC.EDU

Faculty Mentor Department

TJLSOPHS - Physiology and Pharmacology

Abstract/Artist Statement

A detailed understanding of voltage-gated ion channel behavior in electrically excitable organs and tissues, such as those in the nervous system and the heart, is vital for comprehending the mechanistic basis of numerous diseases and syndromes. Comprehensive kinetic modeling has therefore become a critical focus of modern pharmaceutical research. In this work, we have implemented a program for smartphones that provides a simple, yet sophisticated tool that can simulate the activity of ion channels. By downsizing simulation tools to the smartphone, we grant the researcher the ability to generate hypotheses based on the predictions made from detailed kinetic modeling of voltage gated ion channel activity in response to various stimuli. This program consists of a Java-based Android app, which will display the channel behavior calculated by the algorithm, given user-defined input parameters. This program will incorporate known kinetic channel models, as well as enable the user to simulate models with custom properties. At the time of abstract submission, the authors have produced a prototype of the algorithm as well as a general framework for the simulation written in Java. In our presentation, the audience can expect a rudimentary explanation of the function of voltage gated ion channels, an overview of the modeling process, and an interactive demonstration of the app and its potential application to active research.

Location

DeRosa University Center, Ballroom

Start Date

28-4-2018 1:00 PM

End Date

28-4-2018 3:00 PM

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Apr 28th, 1:00 PM Apr 28th, 3:00 PM

Cell Phones in the Lab: An App for the Dynamic Simulation of Voltage-Gated Ion Channels

DeRosa University Center, Ballroom

A detailed understanding of voltage-gated ion channel behavior in electrically excitable organs and tissues, such as those in the nervous system and the heart, is vital for comprehending the mechanistic basis of numerous diseases and syndromes. Comprehensive kinetic modeling has therefore become a critical focus of modern pharmaceutical research. In this work, we have implemented a program for smartphones that provides a simple, yet sophisticated tool that can simulate the activity of ion channels. By downsizing simulation tools to the smartphone, we grant the researcher the ability to generate hypotheses based on the predictions made from detailed kinetic modeling of voltage gated ion channel activity in response to various stimuli. This program consists of a Java-based Android app, which will display the channel behavior calculated by the algorithm, given user-defined input parameters. This program will incorporate known kinetic channel models, as well as enable the user to simulate models with custom properties. At the time of abstract submission, the authors have produced a prototype of the algorithm as well as a general framework for the simulation written in Java. In our presentation, the audience can expect a rudimentary explanation of the function of voltage gated ion channels, an overview of the modeling process, and an interactive demonstration of the app and its potential application to active research.