Title

Quantifying thin film characteristics using a quartz crystal microbalance

Poster Number

01B

Lead Author Major

Bioengineering

Lead Author Status

Sophomore

Format

Poster Presentation

Faculty Mentor Name

Shelly Gulati

Faculty Mentor Email

sgulati@pacific.edu

Faculty Mentor Department

Bioengineering Department

Abstract/Artist Statement

A quartz crystal microbalance (QCM) controlled by Labview is used to measure the frequency sensitivity to masses of thin film. In previous work, a dissolution testing method was developed using a commercial QCM system with a microfluidic flow cell to measure drug dissolution rate. In order to optimize the dissolution testing procedure, a deeper understanding of influence of the thin drug film to the crystal is needed and is the focus this study. The QCM responses to a variety of thin film masses and sample volumes were studied. The thin films are prepared by applying a known volume of benzoic acid in isopropyl alcohol solution onto the crystal, allowing the isopropyl alcohol to evaporate. With time a layer of benzoic acid film becomes visible on the crystal. Simultaneously the QCM records the temporal change in frequency during the process of evaporation. The test was over once the frequency values appeared to have stabilized The relationship between applied mass and the area of crystal coverage was analyzed in order to determine how the surface area of the crystal covered affects the frequency change. Benzoic acid masses of 100, 150, and 200 micrograms were applied to the crystal in 2 and 3 microliter quantities in order to compare if a larger volume applied, and therefore greater surface area, will lead to less variation in frequency changes between trials.

Location

DeRosa University Center, Ballroom

Start Date

29-4-2017 10:00 AM

End Date

29-4-2017 12:00 PM

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Apr 29th, 10:00 AM Apr 29th, 12:00 PM

Quantifying thin film characteristics using a quartz crystal microbalance

DeRosa University Center, Ballroom

A quartz crystal microbalance (QCM) controlled by Labview is used to measure the frequency sensitivity to masses of thin film. In previous work, a dissolution testing method was developed using a commercial QCM system with a microfluidic flow cell to measure drug dissolution rate. In order to optimize the dissolution testing procedure, a deeper understanding of influence of the thin drug film to the crystal is needed and is the focus this study. The QCM responses to a variety of thin film masses and sample volumes were studied. The thin films are prepared by applying a known volume of benzoic acid in isopropyl alcohol solution onto the crystal, allowing the isopropyl alcohol to evaporate. With time a layer of benzoic acid film becomes visible on the crystal. Simultaneously the QCM records the temporal change in frequency during the process of evaporation. The test was over once the frequency values appeared to have stabilized The relationship between applied mass and the area of crystal coverage was analyzed in order to determine how the surface area of the crystal covered affects the frequency change. Benzoic acid masses of 100, 150, and 200 micrograms were applied to the crystal in 2 and 3 microliter quantities in order to compare if a larger volume applied, and therefore greater surface area, will lead to less variation in frequency changes between trials.