Title

Quantifying Drug Dissolution Using a Quartz Crystal Microbalance

Poster Number

22

Lead Author Major

Bioengineering

Format

Poster Presentation

Faculty Mentor Name

Shelly Gulati

Faculty Mentor Department

Bioengineering

Abstract/Artist Statement

Our research team is developing a novel method to measure drug dissolution using a Quartz Crystal Microbalance (QCM). The dissolution rate of a drug is one of the many important characteristics that are carefully measured in the development of new drugs. It one of the many factors that allows us to fully understand the function of a drug and is indicative to the duration that the drug lasts. There are several current apparatuses that are used to measure drug dissolution, however most require test samples to the order of several milligrams per sample. This is even more of a problem when dealing with new drugs under development that are more difficult to extract or expensive to produce. Since each drug is tested through numerous samples and trials, there is a relatively high amount of waste. Our approach will allow users to directly measure mass changes of the drug sample over a continuous duration. Such method will effectively reduce sample size to an order of several micrograms, and possibly onto the nanogram scale. The drug sample is applied onto the quartz crystal as a thin film and then inserted into the QCM. The QCM uses a resonator that vibrates the quartz crystal and applied sample to their resonant frequency. As the sample dissolves in the solvent (under flow in an attached flow cell), the QCM resonator automatically adjusts the frequency accordingly and the mass loss is recorded. This mass loss signature will characterize the dissolution of the drug.

Location

DeRosa University Center, Ballroom

Start Date

20-4-2013 10:00 AM

End Date

20-4-2013 12:00 PM

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Apr 20th, 10:00 AM Apr 20th, 12:00 PM

Quantifying Drug Dissolution Using a Quartz Crystal Microbalance

DeRosa University Center, Ballroom

Our research team is developing a novel method to measure drug dissolution using a Quartz Crystal Microbalance (QCM). The dissolution rate of a drug is one of the many important characteristics that are carefully measured in the development of new drugs. It one of the many factors that allows us to fully understand the function of a drug and is indicative to the duration that the drug lasts. There are several current apparatuses that are used to measure drug dissolution, however most require test samples to the order of several milligrams per sample. This is even more of a problem when dealing with new drugs under development that are more difficult to extract or expensive to produce. Since each drug is tested through numerous samples and trials, there is a relatively high amount of waste. Our approach will allow users to directly measure mass changes of the drug sample over a continuous duration. Such method will effectively reduce sample size to an order of several micrograms, and possibly onto the nanogram scale. The drug sample is applied onto the quartz crystal as a thin film and then inserted into the QCM. The QCM uses a resonator that vibrates the quartz crystal and applied sample to their resonant frequency. As the sample dissolves in the solvent (under flow in an attached flow cell), the QCM resonator automatically adjusts the frequency accordingly and the mass loss is recorded. This mass loss signature will characterize the dissolution of the drug.