Dynamic Reversal of Insulin Sensitivity during Adipogenesis by the Timing and Order of CEBPB and CEBPA Levels
Atefeh Rabiee: 0000-0003-4060-7328
Conference Title/Conference Publication
Research Symposium: 4th Annual Frontiers in Diabetes
April 24, 2019
Date of Presentation
Dysfunctional adipose tissue is a hallmark of insulin resistance (IR), a disease that is highly correlated with diabetes and cardiovascular disease. The development of healthy functioning adipocytes (fat cells) requires that, early in adipogenesis, the expression of the transcription factor C/EBPβ increases, resulting in an upregulation in the expression of its downstream target PPARγ, the master regulator of adipogenesis. Under normal conditions, C/EBPβ expression subsequently decreases as adipogenesis progresses. However, under inflammatory (IR) conditions, expression of C/EBPβ remains high, and reports suggest that this high C/EBPβ contributes to the inflammatory state. Understanding how C/EBPβ switches from being adipogenic (promoting insulin sensitivity) to inflammatory (promoting IR) could be a promising new way to treat IR, but the mechanisms underlying this switch are poorly understood. Here, we present evidence that high C/EBPβ in adipocytes under inflammatory conditions leads to IR by blocking access of C/EBP onto the promoters of adipogenic genes. Here we show that the timing of expression of C/EBPβ and C/EBP needs to be precisely controlled for adipogenesis to correctly progress and disruption of this timing leads to IR.
Rabiee, Atefeh, "Dynamic Reversal of Insulin Sensitivity during Adipogenesis by the Timing and Order of CEBPB and CEBPA Levels" (2015). School of Pharmacy Faculty Presentations. 743.