pH-Triggered conformational switches based on trans-2-aminocyclohexanol moiety
Conference Title/Conference Publication
241st National Meeting and Exposition of the American Chemical Society (ACS)
American Chemical Society (ACS)
March 27-31, 2011
Date of Presentation
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can serve as powerful conformational pH-triggers. Their protonation leads to a conformational flip due to a strong intramolecular hydrogen bond. This 'impulse' is mechanically transmitted by the cycle to induce a conformational change of a remote site, thus altering its properties. Variation of NR2 groups allows a tuning of the conformational equilibrium, which was studied by NMR. These triggers were used in pH-sensitive lipid vesicles for drug and gene delivery.
Samoshin, Vyacheslav V.; Zheng, Yu; Liu, Xin; Samoshina, Nataliya M.; Chertkov, Vyacheslav A.; Franz, Andreas H.; and Guo, Xin, "pH-Triggered conformational switches based on trans-2-aminocyclohexanol moiety" (2011). School of Pharmacy Faculty Presentations. 392.