High Fructose Consumption Exacerbates Metabolic Alterations Compared to Glucose in Female Rats

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FASEB Journal






Supp 1



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High fructose consumption, especially in soft drinks, has been associated with the development of obesity, diabetes and hypertension. The aim of this study was to investigate the effect of liquid fructose and glucose intake on metabolic parameters related to these pathologies in female rats. Sprague-Dawley female rats were supplemented with 20% w/v glucose (G) or fructose (F) in drinking water for 8 weeks. Control (C) rats received no sugar. Body weight, food and drink intake and blood pressure (BP) were monitored throughout the experiment, and after the sacrifice, organ weight and plasma analytes for metabolic parameters were measured. Total caloric intake was significantly increased 1.8-fold and 1.6-fold in G and F groups vs C, respectively. Moreover, calorie consumption was significantly higher in G vs F group (p<0.01). Systolic BP was significantly increased in both G and F groups. Adiposity and plasma leptin levels were also significantly higher in treated groups vs C. However, total body and liver weights, as well as triglyceride (TG) and insulin levels were significantly increased only in F group. Interestingly, plasma adiponectin levels were increased by 3-fold only in G group (p<0.001 vs F and C). In conclusion, despite the higher total caloric consumption in G group, F but not G intake increased insulin and TG levels suggesting insulin resistance. The paradoxical increase in adiponectin levels only in G group might be a mechanism of protection from metabolic alterations. Supported by NIDCR and F. Pedro i Pons.