Document Type
Article
Publication Title
Proceedings of the National Academy of Sciences of the United States of America
ISSN
1091-6490
Volume
117
Issue
38
DOI
10.1073/pnas.2011243117
First Page
23932
Last Page
23941
Publication Date
9-22-2020
Abstract
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.
Recommended Citation
Brandão, B. B.,
Madsen, S.,
Rabiee, A.,
Oliverio, M.,
Ruiz, G. P.,
Ferrucci, D. L.,
Branquinho, J. L.,
Razolli, D.,
Pinto, S.,
Nielsen, T. S.,
Festuccia, W. T.,
Martins, A. S.,
Guerra, B. A.,
Knittel, T. L.,
Søgaard, D.,
Larsen, S.,
Helge, J. W.,
Brandauer, J.,
Velloso, L. A.,
Emanuelli, B.,
Kornfeld, J. W.,
Kahn, C. R.,
Vienberg, S. G.,
Zierath, J. R.,
Treebak, J. T.,
&
Mori, M. A.
(2020).
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23932–23941.
DOI: 10.1073/pnas.2011243117
https://scholarlycommons.pacific.edu/phs-facarticles/438
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