Modifying quinolone antibiotics yields new anxiolytics
Document Type
Article
Publication Title
Nature Medicine
ISSN
1078-8956
Volume
10
Issue
1
DOI
10.1038/nm967
First Page
31
Last Page
32
Publication Date
1-1-2004
Abstract
Patients taking fluoroquinolone antibiotics such as norfloxacin exhibit a low incidence of convulsions and anxiety. These side effects probably result from antagonism of the neurotransmitter γ-aminobutyric acid (GABA) at the brain GABA receptor complex (GRC). Modification of norfloxacin yields molecules such as compound 4 that potentiate GABA action with α subunit selectivity. Compound 4 is anxiolytic but does not cause sedation, and may represent a new class of ligands that have anxiolytic activity without sedative liability. A 2
Recommended Citation
Johnstone, T. B.,
Hogenkamp, D. J.,
Coyne, L.,
Su, J.,
Halliwell, R. F.,
Tran, M. B.,
Yoshimura, R. F.,
Li, W.,
Wang, J.,
&
Gee, K. W.
(2004).
Modifying quinolone antibiotics yields new anxiolytics.
Nature Medicine, 10(1), 31–32.
DOI: 10.1038/nm967
https://scholarlycommons.pacific.edu/phs-facarticles/408
