Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial
Complementary Therapies in Medicine
OBJECTIVE: To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes.
DESIGN: A subgroup analysis was carried out on data from 103 prediabetic patients participating in the "Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics" trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program.
SETTING: Family Medicine Residency, Mike O'Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency.
MAIN OUTCOME MEASURES: QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months.
RESULTS: Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05).
CONCLUSIONS: Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.
Pender, D. N.,
Crawford, P. F.,
Clark, J. M.,
Crawford, A. J.,
Prats, A. A.,
Shah, S. A.
Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial.
Complementary Therapies in Medicine, 41, 302–305.