The scaling problem with the diffusion model. If Bicoid protein specifies the A/P body axis by forming a gradient (head at high concentration, thorax at medium/low concentration, abdomen at no Bicoid), then how do much larger flies get a proper A/P axis? If Bicoid is passively diffusing, it should form a much shallower gradient/body length in larger flies. What are some ways that the developing flies could compensate for this?
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nanos, bicoid, drosophila, axis specification, anteroposterior, evodevo, scaling, development, evolution, diptera